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Literature summary extracted from

  • Poplawski, P.; Rybicka, B.; Boguslawska, J.; Rodzik, K.; Visser, T.J.; Nauman, A.; Piekielko-Witkowska, A.
    Induction of type 1 iodothyronine deiodinase expression inhibits proliferation and migration of renal cancer cells (2017), Mol. Cell. Endocrinol., 442, 58-67 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.99.4 L-thyroxine + reduced acceptor Homo sapiens
-
 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.21.99.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.21.99.4 KIJ-265T cell
-
 Homo sapiens
-
1.21.99.4 KIJ-308T cell
-
 Homo sapiens
-
1.21.99.4 renal cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.99.4 L-thyroxine + reduced acceptor
-
 Homo sapiens 3,3',5-triiodo-L-thyronine + iodide + acceptor + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.21.99.4 ? x * 28000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.21.99.4 DIO1
-
 Homo sapiens
1.21.99.4 type 1 iodothyronine deiodinase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.21.99.4 malfunction enzyme loss contributes to renal carcinogenesis Homo sapiens
1.21.99.4 physiological function enzyme overexpression inhibits migration of renal cancer cells. Induction of DIO1 expression in KIJ265T cells leads to significantly decreased cellular proliferation and affects the expression of cell cycle genes, inhibiting the expression of genes that stimulate G1-to-S transition (e.g. cyclin E1) while stimulating the expression of cell cycle repressor E2F Homo sapiens